Gene description for Pvr
Gene name poliovirus receptor
Gene symbol Pvr
Other names/aliases 3830421F03Rik
CD155
D7Ertd458e
HVED
PVS
Taa1
Tage4
mE4
necl-5
Species Mus musculus
 Database cross references - Pvr
ExoCarta ExoCarta_52118
Vesiclepedia VP_52118
Entrez Gene 52118
 Pvr identified in sEVs derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Pvr
Molecular Function
    virus receptor activity GO:0001618 ISO
    protein binding GO:0005515 IPI
    dynein light chain binding GO:0045503 IPI
    cell adhesion molecule binding GO:0050839 ISO
Biological Process
    positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860 ISO
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IBA
    cell migration GO:0016477 IDA
    susceptibility to natural killer cell mediated cytotoxicity GO:0042271 ISO
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 ISO
    susceptibility to T cell mediated cytotoxicity GO:0060370 ISO
    cell-cell adhesion GO:0098609 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    adherens junction GO:0005912 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Pvr in sEVs
1
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pvr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pvr is involved
No pathways found





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