Gene description for FGA
Gene name fibrinogen alpha chain
Gene symbol FGA
Other names/aliases -
Species Bos taurus
 Database cross references - FGA
ExoCarta ExoCarta_522039
Vesiclepedia VP_522039
Entrez Gene 522039
UniProt P02672  
 FGA identified in sEVs derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for FGA
Molecular Function
    signaling receptor binding GO:0005102 IEA
    extracellular matrix structural constituent GO:0005201 IEA
Biological Process
    blood coagulation GO:0007596 IEA
    platelet activation GO:0030168 IEA
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IEA
    fibrinolysis GO:0042730 IEA
    protein polymerization GO:0051258 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    platelet aggregation GO:0070527 IEA
    blood coagulation, common pathway GO:0072377 IEA
    positive regulation of peptide hormone secretion GO:0090277 IEA
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA
    negative regulation of endothelial cell apoptotic process GO:2000352 IEA
Subcellular Localization
    fibrinogen complex GO:0005577 IEA
 Experiment description of studies that identified FGA in sEVs
1
Experiment ID 187
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors "Ochieng J, Pratap S, Khatua AK, Sakwe AM."
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FGA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FGA is involved
No pathways found





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