Gene description for USP2
Gene name ubiquitin specific peptidase 2
Gene symbol USP2
Other names/aliases -
Species Bos taurus
 Database cross references - USP2
ExoCarta ExoCarta_522980
Entrez Gene 522980
UniProt Q2KHV7  
 USP2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for USP2
Molecular Function
    ubiquitin-specific protease activity GO:0004843 IBA
    cyclin binding GO:0030332 IEA
    identical protein binding GO:0042802 IEA
    ubiquitin protein ligase binding GO:0031625 IEA
    metal ion binding GO:0046872 IEA
    cysteine-type endopeptidase activity GO:0004197 IBA
Biological Process
    protein deubiquitination GO:0016579 ISS
    muscle organ development GO:0007517 IEA
    circadian behavior GO:0048512 ISS
    cell cycle GO:0007049 IEA
    circadian regulation of gene expression GO:0032922 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    protein stabilization GO:0050821 ISS
    locomotor rhythm GO:0045475 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    entrainment of circadian clock by photoperiod GO:0043153 ISS
    regulation of proteasomal protein catabolic process GO:0061136 IBA
    regulation of transcription, DNA-templated GO:0006355 IBA
    positive regulation of mitotic cell cycle GO:0045931 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    nucleus GO:0005634 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
    cell cortex GO:0005938 IEA
 Experiment description of studies that identified USP2 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for USP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which USP2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here