Gene description for IDE
Gene name insulin-degrading enzyme
Gene symbol IDE
Other names/aliases -
Species Bos taurus
 Database cross references - IDE
ExoCarta ExoCarta_523752
Entrez Gene 523752
UniProt Q24K02  
 IDE identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for IDE
Molecular Function
    receptor binding GO:0005102 IEA
    zinc ion binding GO:0008270 ISS
    ATP binding GO:0005524 ISS
    glycoprotein binding GO:0001948 IEA
    insulin binding GO:0043559 IEA
    protein homodimerization activity GO:0042803 IEA
    metalloendopeptidase activity GO:0004222 ISS
    ubiquitin binding GO:0043130 IEA
Biological Process
    ubiquitin homeostasis GO:0010992 IEA
    determination of adult lifespan GO:0008340 IEA
    proteolysis involved in cellular protein catabolic process GO:0051603 IEA
    protein homooligomerization GO:0051260 IEA
    bradykinin catabolic process GO:0010815 ISS
    insulin catabolic process GO:1901143 IEA
    beta-amyloid metabolic process GO:0050435 ISS
    positive regulation of protein oligomerization GO:0032461 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    peroxisome GO:0005777 IEA
    plasma membrane GO:0005886 IEA
    mitochondrion GO:0005739 IEA
    cell surface GO:0009986 IEA
    nucleoplasm GO:0005654 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified IDE in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IDE
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IDE is involved
No pathways found





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