Gene description for Wipi1
Gene name WD repeat domain, phosphoinositide interacting 1
Gene symbol Wipi1
Other names/aliases 4930533H01Rik
AW411817
D11Ertd498e
Species Mus musculus
 Database cross references - Wipi1
ExoCarta ExoCarta_52639
Vesiclepedia VP_52639
Entrez Gene 52639
UniProt Q8R3E3  
 Wipi1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Wipi1
Molecular Function
    receptor binding GO:0005102 ISO
    phosphatidylinositol-3-phosphate binding GO:0032266 ISO
    estrogen receptor binding GO:0030331 ISO
    androgen receptor binding GO:0050681 ISO
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 ISO
Biological Process
    mitochondrion degradation GO:0000422 IBA
    vesicle targeting, trans-Golgi to endosome GO:0048203 ISO
    protein lipidation GO:0006497 IBA
    cellular response to nitrogen starvation GO:0006995 IBA
    protein localization to pre-autophagosomal structure GO:0034497 IBA
    nucleophagy GO:0044804 IBA
    autophagosome assembly GO:0000045 IBA
    autophagy GO:0006914 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IEA
    endosome GO:0005768 IEA
    endosome membrane GO:0010008 ISO
    cytoskeleton GO:0005856 IEA
    cytosol GO:0005829 IBA
    Golgi apparatus GO:0005794 IEA
    autophagosome membrane GO:0000421 ISO
    pre-autophagosomal structure membrane GO:0034045 ISO
    extrinsic component of membrane GO:0019898 IBA
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 ISO
    pre-autophagosomal structure GO:0000407 ISO
    trans-Golgi network GO:0005802 ISO
 Experiment description of studies that identified Wipi1 in exosomes
1
Experiment ID 15
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Wipi1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Wipi1 is involved
No pathways found





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