Gene description for PIGC
Gene name phosphatidylinositol glycan anchor biosynthesis, class C
Gene symbol PIGC
Other names/aliases GPI2
Species Homo sapiens
 Database cross references - PIGC
ExoCarta ExoCarta_5279
Entrez Gene 5279
HGNC 8960
MIM 601730
UniProt Q92535  
 PIGC identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PIGC
Molecular Function
    catalytic activity GO:0003824 TAS
    phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0017176 IEA
Biological Process
    C-terminal protein lipidation GO:0006501 TAS
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
    preassembly of GPI anchor in ER membrane GO:0016254 TAS
    GPI anchor biosynthetic process GO:0006506 TAS
Subcellular Localization
    glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex GO:0000506 IDA
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified PIGC in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PIGC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZHX1  
Two-hybrid Homo sapiens
2 PIGA  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 PIGQ  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 PIGH  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PIGC is involved
PathwayEvidenceSource
Synthesis of glycosylphosphatidylinositol (GPI) TAS Reactome





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