Gene description for PIGC
Gene name phosphatidylinositol glycan anchor biosynthesis, class C
Gene symbol PIGC
Other names/aliases GPI2
Species Homo sapiens
 Database cross references - PIGC
ExoCarta ExoCarta_5279
Vesiclepedia VP_5279
Entrez Gene 5279
HGNC 8960
MIM 601730
UniProt Q92535  
 PIGC identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PIGC
Molecular Function
    catalytic activity GO:0003824 TAS
    protein binding GO:0005515 IPI
Biological Process
    GPI anchor biosynthetic process GO:0006506 IDA
    GPI anchor biosynthetic process GO:0006506 IEA
    GPI anchor biosynthetic process GO:0006506 IMP
Subcellular Localization
    glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex GO:0000506 IBA
    glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex GO:0000506 IDA
    glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex GO:0000506 IPI
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified PIGC in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PIGC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZHX1  
Two-hybrid Homo sapiens
2 ACACA 31
Negative Genetic Homo sapiens
3 PIGQ  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 KLF10  
Two-hybrid Homo sapiens
View the network image/svg+xml



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