Gene description for SNX3
Gene name sorting nexin 3
Gene symbol SNX3
Other names/aliases -
Species Bos taurus
 Database cross references - SNX3
ExoCarta ExoCarta_528265
Entrez Gene 528265
UniProt Q1RMH8  
 SNX3 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SNX3
Molecular Function
    phosphatidylinositol-4-phosphate binding GO:0070273 ISS
    phosphatidylinositol-5-phosphate binding GO:0010314 ISS
    phosphatidylinositol-3-phosphate binding GO:0032266 ISS
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 ISS
    phosphatidylinositol binding GO:0035091 IBA
    protein phosphatase binding GO:0019903 IEA
Biological Process
    hemoglobin biosynthetic process GO:0042541 IEA
    negative regulation of viral entry into host cell GO:0046597 IEA
    intralumenal vesicle formation GO:0070676 IEA
    regulation of cellular protein metabolic process GO:0032268 IEA
    negative regulation of early endosome to late endosome transport GO:2000642 IEA
    endocytosis GO:0006897 IBA
    vesicle organization GO:0016050 IBA
    membrane invagination GO:0010324 IEA
    response to bacterium GO:0009617 IEA
    negative regulation of phagocytosis GO:0050765 ISS
    regulation of Wnt signaling pathway GO:0030111 ISS
    negative regulation of protein catabolic process GO:0042177 IEA
    regulation of intracellular protein transport GO:0033157 IEA
    positive regulation of neuron projection development GO:0010976 ISS
    negative regulation of protein transport GO:0051224 IEA
    protein to membrane docking GO:0022615 ISS
    transferrin transport GO:0033572 IEA
Subcellular Localization
    early phagosome GO:0032009 ISS
    clathrin-coated vesicle GO:0030136 ISS
    early endosome GO:0005769 ISS
    extrinsic component of membrane GO:0019898 IBA
    retromer complex GO:0030904 IEA
    extracellular exosome GO:0070062 IEA
    early endosome membrane GO:0031901 IEA
    cytosol GO:0005829 IEA
    endosome GO:0005768 IBA
    endosome membrane GO:0010008 ISS
 Experiment description of studies that identified SNX3 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNX3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SNX3 is involved
PathwayEvidenceSource
WNT ligand biogenesis and trafficking IEA Reactome





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