Gene description for SFN
Gene name stratifin
Gene symbol SFN
Other names/aliases -
Species Bos taurus
 Database cross references - SFN
ExoCarta ExoCarta_528453
Entrez Gene 528453
UniProt Q0VC36  
 SFN identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SFN
Molecular Function
    protein kinase binding GO:0019901 IEA
    phosphoprotein binding GO:0051219 IEA
    protein domain specific binding GO:0019904 IEA
Biological Process
    regulation of epidermal cell division GO:0010482 ISS
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA
    positive regulation of cell growth GO:0030307 IEA
    positive regulation of epidermal cell differentiation GO:0045606 ISS
    establishment of skin barrier GO:0061436 ISS
    keratinocyte development GO:0003334 IEA
    keratinization GO:0031424 IEA
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 IEA
    positive regulation of protein export from nucleus GO:0046827 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA
    release of cytochrome c from mitochondria GO:0001836 IEA
    negative regulation of keratinocyte proliferation GO:0010839 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified SFN in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SFN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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