Gene description for DNAJA1
Gene name DnaJ (Hsp40) homolog, subfamily A, member 1
Gene symbol DNAJA1
Other names/aliases -
Species Bos taurus
 Database cross references - DNAJA1
ExoCarta ExoCarta_528862
Entrez Gene 528862
UniProt Q5E954  
 DNAJA1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for DNAJA1
Molecular Function
    Hsp70 protein binding GO:0030544 ISS
    low-density lipoprotein particle receptor binding GO:0050750 ISS
    chaperone binding GO:0051087 ISS
    ATP binding GO:0005524 IEA
    unfolded protein binding GO:0051082 IBA
    ubiquitin protein ligase binding GO:0031625 IEA
    metal ion binding GO:0046872 IEA
    G-protein coupled receptor binding GO:0001664 IEA
Biological Process
    negative regulation of protein ubiquitination GO:0031397 IEA
    spermatogenesis GO:0007283 ISS
    positive regulation of apoptotic process GO:0043065 ISS
    androgen receptor signaling pathway GO:0030521 ISS
    toxin transport GO:1901998 IEA
    sperm motility GO:0030317 ISS
    response to heat GO:0009408 IEA
    regulation of protein transport GO:0051223 ISS
    protein localization to mitochondrion GO:0070585 ISS
    protein refolding GO:0042026 IBA
    negative regulation of apoptotic process GO:0043066 ISS
    negative regulation of JUN kinase activity GO:0043508 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    mitochondrion GO:0005739 IEA
    ubiquitin ligase complex GO:0000151 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    nucleus GO:0005634 IEA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IBA
    membrane GO:0016020 IEA
 Experiment description of studies that identified DNAJA1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNAJA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNAJA1 is involved
No pathways found

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