ExoCarta: Gene summary

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Gene description for TMED10
Gene name	transmembrane emp24-like trafficking protein 10 (yeast)
Gene symbol	TMED10
Other names/aliases	TMP21
Species	Bos taurus
Database cross references - TMED10
ExoCarta	ExoCarta_529761
Vesiclepedia	VP_529761
Entrez Gene	529761
UniProt	Q5E971
TMED10 identified in sEVs derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for TMED10

Biological Process
	intracellular protein transport	GO:0006886	IEA
	endoplasmic reticulum to Golgi vesicle-mediated transport	GO:0006888	IEA
	Golgi organization	GO:0007030	IEA
Subcellular Localization
	endoplasmic reticulum	GO:0005783	IEA
	endoplasmic reticulum-Golgi intermediate compartment	GO:0005793	IEA
	Golgi apparatus	GO:0005794	IEA
	COPII-coated ER to Golgi transport vesicle	GO:0030134	IEA
	COPI-coated vesicle	GO:0030137	IEA

Experiment description of studies that identified TMED10 in sEVs

Experiment ID

213

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23459212

Organism

Bos taurus

Experiment description

"Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."

Authors

"Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."

Journal name

J Proteomics

Publication year

2013

Sample

Milk

Sample name

Staphylococcus aureus-infected-Milk

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for TMED10

	Protein Interactor	ExoCarta ID	Identification method	PubMed	Species
No interactions are found.

Pathways in which TMED10 is involved

Pathway	Evidence	Source
Asparagine N-linked glycosylation	IEA	Reactome
Cargo concentration in the ER	IEA	Reactome
COPI-dependent Golgi-to-ER retrograde traffic	IEA	Reactome
COPI-mediated anterograde transport	IEA	Reactome
COPII-mediated vesicle transport	IEA	Reactome
ER to Golgi Anterograde Transport	IEA	Reactome
Golgi-to-ER retrograde transport	IEA	Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic	IEA	Reactome
Membrane Trafficking	IEA	Reactome
Metabolism of proteins	IEA	Reactome
Post-translational protein modification	IEA	Reactome
Transport to the Golgi and subsequent modification	IEA	Reactome
Vesicle-mediated transport	IEA	Reactome

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