Gene description for PCBD1
Gene name pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
Gene symbol PCBD1
Other names/aliases DCoH
PCD
PHS
Species Bos taurus
 Database cross references - PCBD1
ExoCarta ExoCarta_530736
Entrez Gene 530736
UniProt Q3ZBD3  
 PCBD1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PCBD1
Molecular Function
    4-alpha-hydroxytetrahydrobiopterin dehydratase activity GO:0008124 IEA
    phenylalanine 4-monooxygenase activity GO:0004505 IEA
    identical protein binding GO:0042802 IEA
Biological Process
    protein homotetramerization GO:0051289 IEA
    tetrahydrobiopterin biosynthetic process GO:0006729 IEA
    transcription, DNA-templated GO:0006351 IEA
    protein heterooligomerization GO:0051291 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified PCBD1 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PCBD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PCBD1 is involved
PathwayEvidenceSource
Phenylalanine and tyrosine catabolism IEA Reactome





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