Gene description for MSH2
Gene name	mutS homolog 2
Gene symbol	MSH2
Other names/aliases	-
Species	Bos taurus
Database cross references - MSH2
ExoCarta	ExoCarta_533115
Entrez Gene	533115
UniProt	Q3MHE4
MSH2 identified in exosomes derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for MSH2

Molecular Function     protein C-terminus binding GO:0008022 IEA     damaged DNA binding GO:0003684 IBA     centromeric DNA binding GO:0019237 IEA     single base insertion or deletion binding GO:0032138 IBA     MutLalpha complex binding GO:0032405 IEA     protein homodimerization activity GO:0042803 IEA     DNA-dependent ATPase activity GO:0008094 IBA     single guanine insertion binding GO:0032142 IEA     ADP binding GO:0043531 IEA     protein kinase binding GO:0019901 IEA     dinucleotide repeat insertion binding GO:0032181 IEA     oxidized purine DNA binding GO:0032357 IEA     double-strand/single-strand DNA junction binding GO:0000406 IBA     heteroduplex DNA loop binding GO:0000404 IBA     magnesium ion binding GO:0000287 IEA     guanine/thymine mispair binding GO:0032137 IBA     single-stranded DNA binding GO:0003697 IEA     ATP binding GO:0005524 IEA     four-way junction DNA binding GO:0000400 IBA     single thymine insertion binding GO:0032143 IEA     Y-form DNA binding GO:0000403 IBA Biological Process     germ cell development GO:0007281 IEA     isotype switching GO:0045190 IBA     reciprocal meiotic recombination GO:0007131 IBA     maintenance of DNA repeat elements GO:0043570 IBA     postreplication repair GO:0006301 IBA     oxidative phosphorylation GO:0006119 IEA     meiotic gene conversion GO:0006311 IBA     negative regulation of neuron apoptotic process GO:0043524 IEA     in utero embryonic development GO:0001701 IEA     B cell differentiation GO:0030183 IEA     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IBA     cell cycle arrest GO:0007050 IEA     double-strand break repair GO:0006302 IBA     negative regulation of reciprocal meiotic recombination GO:0045128 IBA     response to UV-B GO:0010224 IBA     determination of adult lifespan GO:0008340 IEA     somatic hypermutation of immunoglobulin genes GO:0016446 IBA     male gonad development GO:0008584 IEA     meiotic mismatch repair GO:0000710 IBA     response to X-ray GO:0010165 IBA     positive regulation of helicase activity GO:0051096 IEA     intra-S DNA damage checkpoint GO:0031573 IBA Subcellular Localization     nuclear chromosome GO:0000228 IBA     MutSalpha complex GO:0032301 ISS     MutSbeta complex GO:0032302 IBA     membrane GO:0016020 IEA