Gene description for KLKB1
Gene name kallikrein B, plasma (Fletcher factor) 1
Gene symbol KLKB1
Other names/aliases -
Species Bos taurus
 Database cross references - KLKB1
ExoCarta ExoCarta_533547
Entrez Gene 533547
UniProt Q2KJ63  
 KLKB1 identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for KLKB1
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    fibrinolysis GO:0042730 IEA
    positive regulation of fibrinolysis GO:0051919 IEA
    blood coagulation GO:0007596 IEA
    plasminogen activation GO:0031639 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified KLKB1 in exosomes
1
Experiment ID 187
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KLKB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KLKB1 is involved
PathwayEvidenceSource
Activation of Matrix Metalloproteinases IEA Reactome
Intrinsic Pathway of Fibrin Clot Formation IEA Reactome





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