Gene description for PPP2R5E
Gene name protein phosphatase 2, regulatory subunit B', epsilon isoform
Gene symbol PPP2R5E
Other names/aliases -
Species Bos taurus
 Database cross references - PPP2R5E
ExoCarta ExoCarta_533617
Vesiclepedia VP_533617
Entrez Gene 533617
UniProt A4FV68  
 PPP2R5E identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPP2R5E
Molecular Function
    protein phosphatase activator activity GO:0072542 IEA
Biological Process
    protein dephosphorylation GO:0006470 IEA
    signal transduction GO:0007165 IEA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IEA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified PPP2R5E in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2R5E
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPP2R5E is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Beta-catenin phosphorylation cascade IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Costimulation by the CD28 family IEA Reactome
CTLA4 inhibitory signaling IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Intracellular signaling by second messengers IEA Reactome
M Phase IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
Negative regulation of MAPK pathway IEA Reactome
Negative regulation of the PI3K/AKT network IEA Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Platelet homeostasis IEA Reactome
Platelet sensitization by LDL IEA Reactome
RAF activation IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by WNT IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome





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