Gene description for Prdx4
Gene name peroxiredoxin 4
Gene symbol Prdx4
Other names/aliases AOE372
Prx-iv
Prx4
TRANK
Species Mus musculus
 Database cross references - Prdx4
ExoCarta ExoCarta_53381
Entrez Gene 53381
UniProt O08807  
 Prdx4 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Pancreatic cells 19351151    
 Gene ontology annotations for Prdx4
Molecular Function
    peroxiredoxin activity GO:0051920 IEA
    peroxidase activity GO:0004601 IEA
    antioxidant activity GO:0016209 IEA
    oxidoreductase activity GO:0016491 IEA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    spermatogenesis GO:0007283 IMP
    negative regulation of male germ cell proliferation GO:2000255 IMP
    cell redox homeostasis GO:0045454 IGI
    protein maturation by protein folding GO:0022417 IGI
    reactive oxygen species metabolic process GO:0072593 IDA
    extracellular matrix organization GO:0030198 IGI
    oxidation-reduction process GO:0055114 IMP
    4-hydroxyproline metabolic process GO:0019471 IGI
    male gonad development GO:0008584 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 IDA
    mitochondrion GO:0005739 IDA
    extracellular region GO:0005576 IEA
    smooth endoplasmic reticulum GO:0005790 ISO
    cell GO:0005623 IGI
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Prdx4 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Prdx4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prdx4 is involved
No pathways found





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