Gene description for IRAK1
Gene name interleukin-1 receptor-associated kinase 1
Gene symbol IRAK1
Other names/aliases -
Species Bos taurus
 Database cross references - IRAK1
ExoCarta ExoCarta_533953
Entrez Gene 533953
UniProt Q2LGB3  
 IRAK1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for IRAK1
Molecular Function
    protein heterodimerization activity GO:0046982 IEA
    interleukin-1 receptor binding GO:0005149 IEA
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
Biological Process
    toll-like receptor 2 signaling pathway GO:0034134 IEA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA
    protein autophosphorylation GO:0046777 IEA
    protein oligomerization GO:0051259 IEA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IEA
    toll-like receptor 4 signaling pathway GO:0034142 IEA
    innate immune response GO:0045087 IEA
    regulation of cytokine-mediated signaling pathway GO:0001959 IEA
    interleukin-1-mediated signaling pathway GO:0070498 IEA
    activation of NF-kappaB-inducing kinase activity GO:0007250 IEA
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IEA
    response to peptidoglycan GO:0032494 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    lipid particle GO:0005811 ISS
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified IRAK1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IRAK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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