Gene description for IRAK1
Gene name interleukin-1 receptor-associated kinase 1
Gene symbol IRAK1
Other names/aliases -
Species Bos taurus
 Database cross references - IRAK1
ExoCarta ExoCarta_533953
Vesiclepedia VP_533953
Entrez Gene 533953
UniProt Q2LGB3  
 IRAK1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for IRAK1
Molecular Function
    protein kinase activity GO:0004672 IEA
    protein binding GO:0005515 IEA
    ATP binding GO:0005524 IEA
Biological Process
    protein phosphorylation GO:0006468 IEA
    signal transduction GO:0007165 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified IRAK1 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IRAK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IRAK1 is involved
PathwayEvidenceSource
activated TAK1 mediates p38 MAPK activation IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
Death Receptor Signaling IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Interleukin-1 family signaling IEA Reactome
Interleukin-1 signaling IEA Reactome
Interleukin-17 signaling IEA Reactome
Intracellular signaling by second messengers IEA Reactome
IRAK1 recruits IKK complex IEA Reactome
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IEA Reactome
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IEA Reactome
MAP kinase activation IEA Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
Negative regulation of the PI3K/AKT network IEA Reactome
NF-kB is activated and signals survival IEA Reactome
p75 NTR receptor-mediated signalling IEA Reactome
p75NTR recruits signalling complexes IEA Reactome
p75NTR signals via NF-kB IEA Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome





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