Gene description for OPTN
Gene name optineurin
Gene symbol OPTN
Other names/aliases -
Species Bos taurus
 Database cross references - OPTN
ExoCarta ExoCarta_534150
Vesiclepedia VP_534150
Entrez Gene 534150
 OPTN identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for OPTN
Molecular Function
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IEA
Biological Process
    protein localization to Golgi apparatus GO:0034067 IEA
    regulation of canonical NF-kappaB signal transduction GO:0043122 IEA
    Golgi ribbon formation GO:0090161 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified OPTN in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OPTN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OPTN is involved
No pathways found





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