Gene description for HPX
Gene name hemopexin
Gene symbol HPX
Other names/aliases -
Species Bos taurus
 Database cross references - HPX
ExoCarta ExoCarta_534509
Entrez Gene 534509
UniProt Q3SZV7  
 HPX identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for HPX
Molecular Function
    metal ion binding GO:0046872 IEA
Biological Process
    hemoglobin metabolic process GO:0020027 IEA
    positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IEA
    transport GO:0006810 IEA
    positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA
    heme metabolic process GO:0042168 IEA
    positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 IEA
    positive regulation of immunoglobulin production GO:0002639 IEA
Subcellular Localization
    blood microparticle GO:0072562 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified HPX in exosomes
1
Experiment ID 187
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HPX
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HPX is involved
PathwayEvidenceSource
Scavenging of heme from plasma IEA Reactome





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