Gene description for Timm23
Gene name translocase of inner mitochondrial membrane 23
Gene symbol Timm23
Other names/aliases Tim23
Species Mus musculus
 Database cross references - Timm23
ExoCarta ExoCarta_53600
Vesiclepedia VP_53600
Entrez Gene 53600
 Timm23 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Timm23
Molecular Function
    protein transmembrane transporter activity GO:0008320 IBA
    protein transmembrane transporter activity GO:0008320 IEA
    enzyme binding GO:0019899 ISO
Biological Process
    intracellular protein transport GO:0006886 ISO
    positive regulation of protein processing GO:0010954 ISO
    protein import into mitochondrial matrix GO:0030150 IBA
    protein import into mitochondrial matrix GO:0030150 IEA
    type 2 mitophagy GO:0061734 ISS
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial inner membrane GO:0005743 ISO
    TIM23 mitochondrial import inner membrane translocase complex GO:0005744 IBA
    TIM23 mitochondrial import inner membrane translocase complex GO:0005744 IEA
    TIM23 mitochondrial import inner membrane translocase complex GO:0005744 ISO
    mitochondrial intermembrane space GO:0005758 ISO
    migrasome GO:0140494 IDA
 Experiment description of studies that identified Timm23 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Timm23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Timm23 is involved
No pathways found





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