Gene description for Vti1b
Gene name vesicle transport through interaction with t-SNAREs 1B
Gene symbol Vti1b
Other names/aliases AU015348
GES30
MVti1b
SNARE
Vti1-rp1
Species Mus musculus
 Database cross references - Vti1b
ExoCarta ExoCarta_53612
Entrez Gene 53612
 Vti1b identified in exosomes derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Vti1b
Molecular Function
    SNARE binding GO:0000149 ISO
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
    chloride channel inhibitor activity GO:0019869 ISO
Biological Process
    protein targeting to vacuole GO:0006623 IBA
    protein transport GO:0015031 IEA
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    intracellular protein transport GO:0006886 IEA
    transport GO:0006810 IEA
    vesicle fusion with Golgi apparatus GO:0048280 IBA
    ER to Golgi vesicle-mediated transport GO:0006888 IBA
    vesicle-mediated transport GO:0016192 IEA
    regulation of protein localization to plasma membrane GO:1903076 ISO
    Golgi to vacuole transport GO:0006896 IBA
    retrograde transport, endosome to Golgi GO:0042147 IBA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    integral component of membrane GO:0016021 IEA
    SNARE complex GO:0031201 IBA
    Golgi apparatus GO:0005794 ISO
    vesicle GO:0031982 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    late endosome membrane GO:0031902 ISO
    lysosomal membrane GO:0005765 ISO
    recycling endosome GO:0055037 ISO
    endosome GO:0005768 IEA
    endoplasmic reticulum membrane GO:0005789 IBA
    membrane GO:0016020 IEA
    lysosome GO:0005764 IEA
    ER to Golgi transport vesicle membrane GO:0012507 IBA
 Experiment description of studies that identified Vti1b in exosomes
1
Experiment ID 14
ISEV standards
✔
EM
EV Biophysical techniques
✔
RAB7|RAB11
EV Cytosolic markers
✔
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
✔
DNM
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Vti1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vti1b is involved
No pathways found





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