Gene description for FXR1
Gene name fragile X mental retardation, autosomal homolog 1
Gene symbol FXR1
Other names/aliases -
Species Bos taurus
 Database cross references - FXR1
ExoCarta ExoCarta_536793
Vesiclepedia VP_536793
Entrez Gene 536793
UniProt Q2TBT7  
 FXR1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for FXR1
Molecular Function
    mRNA 3'-UTR binding GO:0003730 IEA
    protein homodimerization activity GO:0042803 IEA
    translation regulator activity GO:0045182 IEA
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IEA
    positive regulation of protein phosphorylation GO:0001934 IEA
    DNA damage response GO:0006974 IEA
    central nervous system development GO:0007417 IEA
    anterograde axonal transport GO:0008089 IEA
    negative regulation of translation GO:0017148 IEA
    regulation of mRNA stability GO:0043488 IEA
    positive regulation of translation GO:0045727 IEA
    regulation of dendrite morphogenesis GO:0048814 IEA
    regulation of filopodium assembly GO:0051489 IEA
    regulation of dendritic spine development GO:0060998 IEA
    regulation of translation at postsynapse, modulating synaptic transmission GO:0099578 IEA
    regulation of modification of synaptic structure GO:1905244 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    postsynaptic density GO:0014069 IEA
    membrane GO:0016020 IEA
    axon GO:0030424 IEA
    growth cone GO:0030426 IEA
    neuronal cell body GO:0043025 IEA
    dendritic spine GO:0043197 IEA
    dendritic spine neck GO:0044326 IEA
    neuronal ribonucleoprotein granule GO:0071598 IEA
    presynapse GO:0098793 IEA
    dendritic filopodium GO:1902737 IEA
 Experiment description of studies that identified FXR1 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FXR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FXR1 is involved
No pathways found





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