Gene description for TOLLIP
Gene name toll interacting protein
Gene symbol TOLLIP
Other names/aliases -
Species Bos taurus
 Database cross references - TOLLIP
ExoCarta ExoCarta_539480
Entrez Gene 539480
UniProt Q2LGB5  
 TOLLIP identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TOLLIP
Molecular Function
    kinase binding GO:0019900 IEA
    Toll-like receptor binding GO:0035325 IEA
Biological Process
    epithelial cell differentiation GO:0030855 IEA
    protein localization to endosome GO:0036010 IEA
    innate immune response GO:0045087 IEA
    autophagy GO:0006914 IEA
    signal transduction GO:0007165 IEA
    inflammatory response GO:0006954 IEA
    phosphorylation GO:0016310 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified TOLLIP in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TOLLIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TOLLIP is involved
PathwayEvidenceSource
Interleukin-1 signaling IEA Reactome





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