Gene description for TOLLIP
Gene name toll interacting protein
Gene symbol TOLLIP
Other names/aliases -
Species Bos taurus
 Database cross references - TOLLIP
ExoCarta ExoCarta_539480
Entrez Gene 539480
UniProt Q2LGB5  
 TOLLIP identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TOLLIP
Molecular Function
    kinase binding GO:0019900 IEA
    Toll-like receptor binding GO:0035325 IEA
Biological Process
    epithelial cell differentiation GO:0030855 IEA
    protein localization to endosome GO:0036010 IEA
    innate immune response GO:0045087 IEA
    autophagy GO:0006914 IEA
    signal transduction GO:0007165 IEA
    inflammatory response GO:0006954 IEA
    phosphorylation GO:0016310 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified TOLLIP in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TOLLIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TOLLIP is involved
Interleukin-1 signaling IEA Reactome

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