Gene description for ARL3
Gene name ADP-ribosylation factor-like 3
Gene symbol ARL3
Other names/aliases -
Species Bos taurus
 Database cross references - ARL3
ExoCarta ExoCarta_540040
Entrez Gene 540040
UniProt Q2TBW6  
 ARL3 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ARL3
Molecular Function
    microtubule binding GO:0008017 ISS
    GDP binding GO:0019003 ISS
    metal ion binding GO:0046872 IEA
    GTP binding GO:0005525 ISS
    GTPase activity GO:0003924 ISS
Biological Process
    protein transport GO:0015031 IEA
    post-Golgi vesicle-mediated transport GO:0006892 IEA
    small GTPase mediated signal transduction GO:0007264 ISS
    photoreceptor cell development GO:0042461 ISS
    cilium morphogenesis GO:0060271 ISS
    intraciliary transport GO:0042073 IEA
    kidney development GO:0001822 ISS
    smoothened signaling pathway GO:0007224 IEA
    metabolic process GO:0008152 ISS
    cytokinesis GO:0000910 ISS
Subcellular Localization
    primary cilium GO:0072372 ISS
    midbody GO:0030496 ISS
    cytoplasmic microtubule GO:0005881 ISS
    spindle microtubule GO:0005876 ISS
    photoreceptor connecting cilium GO:0032391 ISS
    extracellular exosome GO:0070062 IEA
    Golgi apparatus GO:0005794 ISS
    centrosome GO:0005813 ISS
    nucleus GO:0005634 ISS
    Golgi membrane GO:0000139 IEA
 Experiment description of studies that identified ARL3 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ARL3 is involved
Trafficking of myristoylated proteins to the cilium IEA Reactome

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