Gene description for DNM1L
Gene name dynamin 1-like
Gene symbol DNM1L
Other names/aliases -
Species Bos taurus
 Database cross references - DNM1L
ExoCarta ExoCarta_540892
Entrez Gene 540892
UniProt Q2KIA5  
 DNM1L identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for DNM1L
Molecular Function
    ubiquitin protein ligase binding GO:0031625 IEA
    GTPase activity GO:0003924 ISS
    lipid binding GO:0008289 IEA
    protein homodimerization activity GO:0042803 ISS
    GTP binding GO:0005525 IEA
Biological Process
    positive regulation of release of cytochrome c from mitochondria GO:0090200 IEA
    metabolic process GO:0008152 ISS
    membrane fusion GO:0061025 IEA
    mitochondrial fragmentation involved in apoptotic process GO:0043653 IEA
    mitochondrial fission GO:0000266 ISS
    protein localization to mitochondrion GO:0070585 IEA
    protein homotetramerization GO:0051289 IEA
    release of cytochrome c from mitochondria GO:0001836 IEA
    mitochondrion morphogenesis GO:0070584 IEA
    endocytosis GO:0006897 IEA
    positive regulation of protein secretion GO:0050714 IEA
    regulation of peroxisome organization GO:1900063 IEA
    dynamin polymerization involved in mitochondrial fission GO:0003374 ISS
    regulation of protein oligomerization GO:0032459 IEA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IEA
    peroxisome fission GO:0016559 ISS
    necroptotic process GO:0070266 ISS
    mitochondrial membrane fission GO:0090149 IEA
Subcellular Localization
    cell junction GO:0030054 IEA
    coated pit GO:0005905 IEA
    synaptic vesicle membrane GO:0030672 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    peroxisome GO:0005777 ISS
    mitochondrial outer membrane GO:0005741 IEA
    Golgi apparatus GO:0005794 IEA
    microtubule GO:0005874 IEA
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified DNM1L in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNM1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNM1L is involved
Apoptotic execution phase IEA Reactome

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