Gene description for THBS4
Gene name thrombospondin 4
Gene symbol THBS4
Other names/aliases TSP-4
Species Bos taurus
 Database cross references - THBS4
ExoCarta ExoCarta_541281
Entrez Gene 541281
UniProt Q3SWW8  
 THBS4 identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for THBS4
Molecular Function
    calcium ion binding GO:0005509 IEA
    integrin binding GO:0005178 IEA
    heparin binding GO:0008201 IEA
    growth factor activity GO:0008083 IEA
Biological Process
    behavioral response to pain GO:0048266 ISS
    response to unfolded protein GO:0006986 IEA
    regulation of tissue remodeling GO:0034103 ISS
    negative regulation of angiogenesis GO:0016525 IEA
    positive regulation of neutrophil chemotaxis GO:0090023 IEA
    myoblast migration GO:0051451 IEA
    tissue remodeling GO:0048771 IEA
    positive regulation of cell division GO:0051781 IEA
    endothelial cell-cell adhesion GO:0071603 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of endothelial cell proliferation GO:0001938 IEA
    response to endoplasmic reticulum stress GO:0034976 ISS
Subcellular Localization
    sarcoplasmic reticulum GO:0016529 ISS
    extracellular space GO:0005615 ISS
    extracellular matrix GO:0031012 ISS
    basement membrane GO:0005604 IEA
    extracellular exosome GO:0070062 IEA
    endoplasmic reticulum GO:0005783 ISS
 Experiment description of studies that identified THBS4 in exosomes
1
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for THBS4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which THBS4 is involved
PathwayEvidenceSource
Signaling by PDGF IEA Reactome





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