Gene description for SASH3
Gene name SAM and SH3 domain containing 3
Gene symbol SASH3
Other names/aliases 753P9
CXorf9
HACS2
SH3D6C
SLY
Species Homo sapiens
 Database cross references - SASH3
ExoCarta ExoCarta_54440
Entrez Gene 54440
HGNC 15975
MIM 300441
UniProt O75995  
 SASH3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SASH3
Biological Process
    positive regulation of interferon-gamma production GO:0032729 IEA
    positive regulation of organ growth GO:0046622 IEA
    positive regulation of T cell cytokine production GO:0002726 IEA
    positive regulation of interleukin-4 production GO:0032753 IEA
    positive regulation of immunoglobulin production GO:0002639 IEA
    positive regulation of interleukin-2 production GO:0032743 IEA
    homeostasis of number of cells within a tissue GO:0048873 IEA
    positive regulation of B cell proliferation GO:0030890 IEA
    positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372 IEA
    positive regulation of interleukin-10 production GO:0032733 IEA
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    positive regulation of T cell proliferation GO:0042102 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified SASH3 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SASH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SASH3 is involved
No pathways found





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