Gene description for Nfat5
Gene name nuclear factor of activated T cells 5
Gene symbol Nfat5
Other names/aliases AI225870
B130038B15Rik
CAG-8
CAG80
NFATL1
OREBP
TonEBP
mKIAA0827
nfatz
Species Mus musculus
 Database cross references - Nfat5
ExoCarta ExoCarta_54446
Entrez Gene 54446
UniProt Q9WV30  
 Nfat5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nfat5
Molecular Function
    DNA binding GO:0003677 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 ISS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
Biological Process
    transcription, DNA-templated GO:0006351 ISS
    regulation of calcineurin-NFAT signaling cascade GO:0070884 IDA
    cytokine production GO:0001816 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of gene expression GO:0010628 IDA
    regulation of transcription, DNA-templated GO:0006355 ISS
    transcription from RNA polymerase II promoter GO:0006366 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Nfat5 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nfat5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nfat5 is involved
No pathways found





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