Gene description for Nfat5
Gene name nuclear factor of activated T cells 5
Gene symbol Nfat5
Other names/aliases AI225870
B130038B15Rik
CAG-8
CAG80
NFATL1
OREBP
TonEBP
mKIAA0827
nfatz
Species Mus musculus
 Database cross references - Nfat5
ExoCarta ExoCarta_54446
Vesiclepedia VP_54446
Entrez Gene 54446
UniProt Q9WV30  
 Nfat5 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nfat5
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 ISO
    chromatin binding GO:0003682 ISS
    DNA-binding transcription factor activity GO:0003700 TAS
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    cytokine production GO:0001816 IDA
    renal water homeostasis GO:0003091 TAS
    DNA-templated transcription GO:0006351 TAS
    DNA damage response GO:0006974 ISO
    DNA damage response GO:0006974 ISS
    response to water deprivation GO:0009414 TAS
    positive regulation of gene expression GO:0010628 IDA
    calcineurin-NFAT signaling cascade GO:0033173 IBA
    negative regulation of urine volume GO:0035811 TAS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    R-loop processing GO:0062176 ISO
    R-loop processing GO:0062176 ISS
    regulation of calcineurin-NFAT signaling cascade GO:0070884 IDA
    cellular response to cytokine stimulus GO:0071345 IEA
    cellular response to cytokine stimulus GO:0071345 ISO
    positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 IEA
    positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    transcription regulator complex GO:0005667 IBA
    chromosome GO:0005694 IEA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Nfat5 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nfat5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Nfat5 is involved
No pathways found





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