Gene description for Pde3a
Gene name	phosphodiesterase 3A, cGMP inhibited
Gene symbol	Pde3a
Other names/aliases	A930022O17Rik C87899
Species	Mus musculus
Database cross references - Pde3a
ExoCarta	ExoCarta_54611
Vesiclepedia	VP_54611
Entrez Gene	54611
UniProt	Q9Z0X4
Pde3a identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Pde3a

Molecular Function     3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 ISO     3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 IBA     3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 IDA     3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 ISO     3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118 IEA     3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity GO:0004119 IEA     3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity GO:0004119 ISO     nuclear estrogen receptor activity GO:0030284 IEA     nuclear estrogen receptor activity GO:0030284 ISO     metal ion binding GO:0046872 IEA     3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 IBA     3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 IEA     3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 ISO     estrogen binding GO:0099130 ISO     estrogen binding GO:0099130 ISS Biological Process     oocyte maturation GO:0001556 IDA     response to xenobiotic stimulus GO:0009410 IDA     cAMP-mediated signaling GO:0019933 IBA     cAMP-mediated signaling GO:0019933 ISO     cGMP-mediated signaling GO:0019934 IEA     cGMP-mediated signaling GO:0019934 ISO     regulation of meiotic nuclear division GO:0040020 IDA     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of vascular permeability GO:0043116 IEA     negative regulation of vascular permeability GO:0043116 ISO     positive regulation of vascular permeability GO:0043117 IEA     positive regulation of vascular permeability GO:0043117 ISO     steroid hormone receptor signaling pathway GO:0043401 IEA     negative regulation of cAMP-mediated signaling GO:0043951 IEA     negative regulation of cAMP-mediated signaling GO:0043951 ISO     oocyte development GO:0048599 IGI     positive regulation of oocyte development GO:0060282 IGI     regulation of ribonuclease activity GO:0060700 ISO     regulation of ribonuclease activity GO:0060700 ISS     cellular response to cGMP GO:0071321 IEA     cellular response to cGMP GO:0071321 ISO     cellular response to transforming growth factor beta stimulus GO:0071560 IEA     apoptotic signaling pathway GO:0097190 ISO     apoptotic signaling pathway GO:0097190 ISS     negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 IEA     negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 ISO Subcellular Localization     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 ISO     membrane GO:0016020 IDA