Gene description for ASPN
Gene name asporin
Gene symbol ASPN
Other names/aliases OS3
PLAP-1
PLAP1
SLRR1C
Species Homo sapiens
 Database cross references - ASPN
ExoCarta ExoCarta_54829
Entrez Gene 54829
HGNC 14872
MIM 608135
UniProt Q9BXN1  
 ASPN identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ASPN
Molecular Function
    collagen binding GO:0005518 IEA
    calcium ion binding GO:0005509 IDA
Biological Process
    bone mineralization GO:0030282 IDA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA
    negative regulation of tooth mineralization GO:0070171 ISS
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IDA
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified ASPN in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ASPN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ASPN is involved
PathwayEvidenceSource
ECM proteoglycans TAS Reactome





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