Gene description for ZCCHC2
Gene name zinc finger, CCHC domain containing 2
Gene symbol ZCCHC2
Other names/aliases C18orf49
Species Homo sapiens
 Database cross references - ZCCHC2
ExoCarta ExoCarta_54877
Vesiclepedia VP_54877
Entrez Gene 54877
HGNC 22916
UniProt Q9C0B9  
 ZCCHC2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZCCHC2
Molecular Function
    nucleic acid binding GO:0003676 IEA
    zinc ion binding GO:0008270 IEA
    phosphatidylinositol binding GO:0035091 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified ZCCHC2 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZCCHC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 TXNIP 10628
Affinity Capture-MS Homo sapiens
3 SQSTM1 8878
Proximity Label-MS Homo sapiens
4 ARRDC2  
Affinity Capture-MS Homo sapiens
5 ARRDC3 57561
Affinity Capture-MS Homo sapiens
6 ARMC8 25852
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZCCHC2 is involved
No pathways found





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