Gene description for SLC22A11
Gene name solute carrier family 22 (organic anion/urate transporter), member 11
Gene symbol SLC22A11
Other names/aliases OAT4
hOAT4
Species Homo sapiens
 Database cross references - SLC22A11
ExoCarta ExoCarta_55867
Vesiclepedia VP_55867
Entrez Gene 55867
HGNC 18120
MIM 607097
UniProt Q9NSA0  
 SLC22A11 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A11
Molecular Function
    solute:inorganic anion antiporter activity GO:0005452 IDA
    protein binding GO:0005515 IPI
    organic anion transmembrane transporter activity GO:0008514 IDA
    prostaglandin transmembrane transporter activity GO:0015132 IDA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IDA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 TAS
Biological Process
    monoatomic ion transport GO:0006811 IEA
    inorganic anion transport GO:0015698 IEA
    organic anion transport GO:0015711 IBA
    organic anion transport GO:0015711 IDA
    prostaglandin transport GO:0015732 IDA
    urate metabolic process GO:0046415 IMP
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IDA
    basal plasma membrane GO:0009925 IEA
    apical plasma membrane GO:0016324 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC22A11 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FUS 2521
Affinity Capture-MS Homo sapiens
2 NEDD4L 23327
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 RRP1B 23076
Affinity Capture-MS Homo sapiens
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