Gene description for SLC22A11
Gene name solute carrier family 22 (organic anion/urate transporter), member 11
Gene symbol SLC22A11
Other names/aliases OAT4
hOAT4
Species Homo sapiens
 Database cross references - SLC22A11
ExoCarta ExoCarta_55867
Entrez Gene 55867
HGNC 18120
MIM 607097
UniProt Q9NSA0  
 SLC22A11 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A11
Molecular Function
    protein binding GO:0005515 IPI
    inorganic anion exchanger activity GO:0005452 IDA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IDA
    organic anion transmembrane transporter activity GO:0008514 IDA
Biological Process
    transmembrane transport GO:0055085 TAS
    organic anion transport GO:0015711 IDA
    urate metabolic process GO:0046415 IMP
    anion transmembrane transport GO:0098656 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IDA
    apical plasma membrane GO:0016324 IDA
    external side of plasma membrane GO:0009897 IDA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLC22A11 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC22A11 is involved
PathwayEvidenceSource
Organic anion transport TAS Reactome





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