Gene description for Apom
Gene name apolipoprotein M
Gene symbol Apom
Other names/aliases 1190010O19Rik
G3a
NG20
Species Mus musculus
 Database cross references - Apom
ExoCarta ExoCarta_55938
Entrez Gene 55938
UniProt Q9Z1R3  
 Apom identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Apom
Molecular Function
    antioxidant activity GO:0016209 ISO
    phospholipid binding GO:0005543 ISS
    lipid transporter activity GO:0005319 ISO
Biological Process
    high-density lipoprotein particle clearance GO:0034384 IMP
    reverse cholesterol transport GO:0043691 IMP
    high-density lipoprotein particle remodeling GO:0034375 ISO
    high-density lipoprotein particle assembly GO:0034380 IMP
    lipid transport GO:0006869 IEA
    negative regulation of plasma lipoprotein particle oxidation GO:0034445 ISO
    transport GO:0006810 IEA
    cholesterol efflux GO:0033344 ISO
    lipoprotein metabolic process GO:0042157 IMP
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    spherical high-density lipoprotein particle GO:0034366 ISO
    extracellular region GO:0005576 IDA
    low-density lipoprotein particle GO:0034362 ISO
    very-low-density lipoprotein particle GO:0034361 ISO
    discoidal high-density lipoprotein particle GO:0034365 ISO
    high-density lipoprotein particle GO:0034364 ISO
 Experiment description of studies that identified Apom in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Apom
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Apom is involved
PathwayEvidenceSource
Retinoid metabolism and transport IEA Reactome





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