Gene description for Impa1
Gene name inositol (myo)-1(or 4)-monophosphatase 1
Gene symbol Impa1
Other names/aliases 2610002K09Rik
2900059K10Rik
AI325909
Species Mus musculus
 Database cross references - Impa1
ExoCarta ExoCarta_55980
Vesiclepedia VP_55980
Entrez Gene 55980
 Impa1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Impa1
Molecular Function
    inositol monophosphate 4-phosphatase activity GO:0052833 IEA
    hydrolase activity GO:0016787 IEA
    inositol monophosphate 3-phosphatase activity GO:0052832 IEA
    identical protein binding GO:0042802 ISO
    lithium ion binding GO:0031403 ISO
    protein homodimerization activity GO:0042803 ISO
    inositol monophosphate phosphatase activity GO:0052834 ISO
    metal ion binding GO:0046872 IEA
    inositol monophosphate 1-phosphatase activity GO:0008934 ISO
    magnesium ion binding GO:0000287 ISO
    manganese ion binding GO:0030145 ISO
Biological Process
    phosphatidylinositol phosphorylation GO:0046854 IEA
    phosphatidylinositol biosynthetic process GO:0006661 ISO
    inositol phosphate dephosphorylation GO:0046855 ISO
    signal transduction GO:0007165 ISO
    inositol metabolic process GO:0006020 TAS
    phosphate-containing compound metabolic process GO:0006796 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    axon GO:0030424 ISO
    neuronal cell body GO:0043025 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Impa1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Impa1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Impa1 is involved
No pathways found





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