Gene description for Nptn
Gene name neuroplastin
Gene symbol Nptn
Other names/aliases Sdfr1
Species Rattus norvegicus
 Database cross references - Nptn
ExoCarta ExoCarta_56064
Entrez Gene 56064
UniProt P97546  
 Nptn identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Nptn
Molecular Function
    fibroblast growth factor receptor binding GO:0005104 IDA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    ion channel binding GO:0044325 IPI
    type 1 fibroblast growth factor receptor binding GO:0005105 IDA
    cell adhesion molecule binding GO:0050839 IDA
Biological Process
    positive regulation of neuron projection development GO:0010976 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    positive regulation of long-term synaptic potentiation GO:1900273 IMP
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IDA
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IDA
    positive regulation of long-term neuronal synaptic plasticity GO:0048170 IMP
    visual learning GO:0008542 IDA
    regulation of cell adhesion GO:0030155 TAS
    positive regulation of cellular protein localization GO:1903829 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    long-term synaptic potentiation GO:0060291 IDA
    positive regulation of protein phosphorylation GO:0001934 IDA
Subcellular Localization
    inhibitory synapse GO:0060077 IDA
    integral component of membrane GO:0016021 TAS
    cytosol GO:0005829 IDA
    synaptic membrane GO:0097060 IDA
    presynaptic membrane GO:0042734 IDA
    cell surface GO:0009986 ISO
    dendrite GO:0030425 IDA
    postsynaptic density GO:0014069 IDA
    postsynaptic membrane GO:0045211 TAS
 Experiment description of studies that identified Nptn in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Nptn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nptn is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here