Gene description for Tgm2
Gene name transglutaminase 2
Gene symbol Tgm2
Other names/aliases TgaseII
Species Rattus norvegicus
 Database cross references - Tgm2
ExoCarta ExoCarta_56083
Entrez Gene 56083
 Tgm2 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tgm2
Molecular Function
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 ISO
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 IPI
    enzyme binding GO:0019899 IC
    GTP binding GO:0005525 IDA
Biological Process
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 ISO
    positive regulation of inflammatory response GO:0050729 IMP
    phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IDA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    salivary gland cavitation GO:0060662 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    protein homooligomerization GO:0051260 IDA
    blood vessel remodeling GO:0001974 IMP
    positive regulation of smooth muscle cell proliferation GO:0048661 IDA
    peptide cross-linking GO:0018149 IEA
    isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine GO:0018153 IDA
    branching involved in salivary gland morphogenesis GO:0060445 ISO
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 IMP
    positive regulation of cell adhesion GO:0045785 ISO
    positive regulation of mitochondrial calcium ion concentration GO:0051561 ISO
    apoptotic cell clearance GO:0043277 ISO
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    cytosol GO:0005829 ISO
    extracellular exosome GO:0070062 ISO
    intrinsic component of plasma membrane GO:0031226 ISO
    mitochondrion GO:0005739 ISO
    focal adhesion GO:0005925 ISO
    plasma membrane GO:0005886 IDA
    cell GO:0005623 ISO
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Tgm2 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tgm2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tgm2 is involved
No pathways found





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