Gene description for Tgm2
Gene name transglutaminase 2
Gene symbol Tgm2
Other names/aliases TgaseII
Species Rattus norvegicus
 Database cross references - Tgm2
ExoCarta ExoCarta_56083
Vesiclepedia VP_56083
Entrez Gene 56083
 Tgm2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tgm2
Molecular Function
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 IBA
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 IEA
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 ISO
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    GTP binding GO:0005525 IDA
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 ISO
    peptidase activity GO:0008233 IEA
    enzyme binding GO:0019899 IC
    protein domain specific binding GO:0019904 IPI
    identical protein binding GO:0042802 IPI
    phospholipase binding GO:0043274 IPI
    metal ion binding GO:0046872 IEA
    protein-glutamine glutaminase activity GO:0050568 IEA
    protein-glutamine glutaminase activity GO:0050568 ISO
    protein-glutamine glutaminase activity GO:0050568 ISS
    histone serotonyltransferase activity GO:0120295 IEA
    histone serotonyltransferase activity GO:0120295 ISO
    histone serotonyltransferase activity GO:0120295 ISS
    histone dopaminyltransferase activity GO:0120297 IEA
    histone dopaminyltransferase activity GO:0120297 ISO
    histone dopaminyltransferase activity GO:0120297 ISS
    peptide histaminyltransferase activity GO:0120299 IEA
    peptide histaminyltransferase activity GO:0120299 ISO
    peptide histaminyltransferase activity GO:0120299 ISS
Biological Process
    blood vessel remodeling GO:0001974 IMP
    chromatin remodeling GO:0006338 IEA
    proteolysis GO:0006508 IEA
    G protein-coupled receptor signaling pathway GO:0007186 ISO
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IBA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IDA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISO
    gene expression GO:0010467 IEA
    gene expression GO:0010467 ISO
    dopamine secretion GO:0014046 IEA
    dopamine secretion GO:0014046 ISO
    peptide cross-linking GO:0018149 ISO
    isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine GO:0018153 IDA
    isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine GO:0018153 ISO
    protein deamination GO:0018277 ISO
    protein deamination GO:0018277 ISS
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IEA
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 ISO
    regulation of apoptotic process GO:0042981 ISO
    regulation of apoptotic process GO:0042981 ISS
    positive regulation of apoptotic process GO:0043065 IBA
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of apoptotic process GO:0043065 IMP
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of apoptotic process GO:0043065 ISS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    apoptotic cell clearance GO:0043277 IEA
    apoptotic cell clearance GO:0043277 ISO
    positive regulation of GTPase activity GO:0043547 ISS
    positive regulation of cell adhesion GO:0045785 IEA
    positive regulation of cell adhesion GO:0045785 ISO
    positive regulation of smooth muscle cell proliferation GO:0048661 IDA
    positive regulation of neurogenesis GO:0050769 IEA
    positive regulation of neurogenesis GO:0050769 ISO
    positive regulation of small GTPase mediated signal transduction GO:0051057 ISS
    protein homooligomerization GO:0051260 ISO
    protein homooligomerization GO:0051260 ISS
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IEA
    positive regulation of mitochondrial calcium ion concentration GO:0051561 ISO
    bone development GO:0060348 ISS
    branching involved in salivary gland morphogenesis GO:0060445 IEA
    branching involved in salivary gland morphogenesis GO:0060445 ISO
    salivary gland cavitation GO:0060662 IEA
    salivary gland cavitation GO:0060662 ISO
    cellular response to cocaine GO:0071314 IEA
    cellular response to cocaine GO:0071314 ISO
    cellular response to dopamine GO:1903351 IEA
    cellular response to dopamine GO:1903351 ISO
    cellular response to dopamine GO:1903351 ISS
    positive regulation of sprouting angiogenesis GO:1903672 IEA
    positive regulation of sprouting angiogenesis GO:1903672 ISO
    cellular response to serotonin GO:1904015 IEA
    cellular response to serotonin GO:1904015 ISO
    cellular response to serotonin GO:1904015 ISS
    regulation of apoptotic cell clearance GO:2000425 IEA
    regulation of apoptotic cell clearance GO:2000425 ISO
    regulation of apoptotic cell clearance GO:2000425 ISS
Subcellular Localization
    chromatin GO:0000785 ISO
    chromatin GO:0000785 ISS
    nucleosome GO:0000786 IEA
    nucleosome GO:0000786 ISO
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    chromosome GO:0005694 IEA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    extracellular matrix GO:0031012 IEA
    extracellular matrix GO:0031012 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Tgm2 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tgm2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tgm2 is involved
No pathways found





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