Gene description for Stk3
Gene name	serine/threonine kinase 3
Gene symbol	Stk3
Other names/aliases	0610042I06Rik MST Mst2 Mst3 Ste20 mess1
Species	Mus musculus
Database cross references - Stk3
ExoCarta	ExoCarta_56274
Vesiclepedia	VP_56274
Entrez Gene	56274
UniProt	Q9JI10
Stk3 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Stk3

Molecular Function     magnesium ion binding GO:0000287 ISO     magnesium ion binding GO:0000287 ISS     protein kinase activity GO:0004672 ISO     protein kinase activity GO:0004672 ISS     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 ISO     protein serine/threonine kinase activity GO:0004674 ISS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 ISO     ATP binding GO:0005524 ISS     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     transcription regulator activator activity GO:0140537 ISO     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     neural tube formation GO:0001841 IGI     endocardium development GO:0003157 IGI     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 ISO     protein import into nucleus GO:0006606 IEA     protein import into nucleus GO:0006606 ISO     apoptotic process GO:0006915 IGI     JNK cascade GO:0007254 IGI     central nervous system development GO:0007417 IGI     cell population proliferation GO:0008283 IGI     negative regulation of cell population proliferation GO:0008285 IGI     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IGI     regulation of gene expression GO:0010468 IEA     organ growth GO:0035265 IGI     hippo signaling GO:0035329 IMP     hippo signaling GO:0035329 ISO     hippo signaling GO:0035329 ISS     positive regulation of hippo signaling GO:0035332 ISO     intracellular signal transduction GO:0035556 IBA     intracellular signal transduction GO:0035556 ISO     intracellular signal transduction GO:0035556 ISS     positive regulation of apoptotic process GO:0043065 IBA     positive regulation of apoptotic process GO:0043065 IGI     positive regulation of apoptotic process GO:0043065 ISS     regulation of MAPK cascade GO:0043408 IBA     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IGI     positive regulation of fat cell differentiation GO:0045600 IGI     positive regulation of JNK cascade GO:0046330 IGI     negative regulation of organ growth GO:0046621 IGI     epithelial cell proliferation GO:0050673 IGI     negative regulation of epithelial cell proliferation GO:0050680 IGI     protein stabilization GO:0050821 ISO     protein tetramerization GO:0051262 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI     canonical Wnt signaling pathway GO:0060070 IGI     primitive hemopoiesis GO:0060215 IGI     cell differentiation involved in embryonic placenta development GO:0060706 IGI     regulation of cell differentiation involved in embryonic placenta development GO:0060800 IGI     protein localization to centrosome GO:0071539 IEA     protein localization to centrosome GO:0071539 ISO     negative regulation of canonical Wnt signaling pathway GO:0090090 IBA     negative regulation of canonical Wnt signaling pathway GO:0090090 IGI     negative regulation of canonical Wnt signaling pathway GO:0090090 ISO     hepatocyte apoptotic process GO:0097284 IGI     positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 IGI Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISO     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     protein-containing complex GO:0032991 ISO