Gene description for Arl2
Gene name ADP-ribosylation factor-like 2
Gene symbol Arl2
Other names/aliases 2610009M23Rik
AI115441
AW553335
Species Mus musculus
 Database cross references - Arl2
ExoCarta ExoCarta_56327
Vesiclepedia VP_56327
Entrez Gene 56327
UniProt Q9D0J4  
 Arl2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Arl2
Molecular Function
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IDA
    GTP binding GO:0005525 ISO
    GDP binding GO:0019003 IDA
Biological Process
    regulation of glycolytic process GO:0006110 ISO
    regulation of glycolytic process GO:0006110 ISS
    protein folding GO:0006457 IBA
    centrosome cycle GO:0007098 ISO
    centrosome cycle GO:0007098 ISS
    positive regulation of cell-substrate adhesion GO:0010811 ISS
    acetylcholine transport GO:0015870 ISO
    regulation of microtubule polymerization GO:0031113 ISO
    regulation of microtubule polymerization GO:0031113 ISS
    positive regulation of microtubule polymerization GO:0031116 ISO
    positive regulation of microtubule polymerization GO:0031116 ISS
    negative regulation of GTPase activity GO:0034260 ISO
    negative regulation of GTPase activity GO:0034260 ISS
    maintenance of protein location in nucleus GO:0051457 ISO
    maintenance of protein location in nucleus GO:0051457 ISS
    bicellular tight junction assembly GO:0070830 ISS
    regulation of aerobic respiration GO:1903715 ISO
    regulation of aerobic respiration GO:1903715 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 ISO
    mitochondrion GO:0005739 ISS
    mitochondrial intermembrane space GO:0005758 IEA
    mitochondrial intermembrane space GO:0005758 ISO
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    centrosome GO:0005813 ISO
    centrosome GO:0005813 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    focal adhesion GO:0005925 IEA
    focal adhesion GO:0005925 ISO
    microtubule cytoskeleton GO:0015630 IBA
    lateral plasma membrane GO:0016328 ISS
 Experiment description of studies that identified Arl2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Arl2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 PDE6D 5147
Two-hybrid Homo sapiens
3 Eed  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here