Gene description for Arl2
Gene name ADP-ribosylation factor-like 2
Gene symbol Arl2
Other names/aliases 2610009M23Rik
AI115441
AW553335
Species Mus musculus
 Database cross references - Arl2
ExoCarta ExoCarta_56327
Entrez Gene 56327
UniProt Q9D0J4  
 Arl2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Arl2
Molecular Function
    GTPase activity GO:0003924 ISO
    GTP binding GO:0005525 ISO
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    GDP binding GO:0019003 IDA
Biological Process
    centrosome organization GO:0051297 ISO
    acetylcholine transport GO:0015870 ISO
    negative regulation of GTPase activity GO:0034260 ISO
    regulation of microtubule polymerization GO:0031113 ISO
    positive regulation of microtubule polymerization GO:0031116 ISO
    small GTPase mediated signal transduction GO:0007264 IEA
    cell cycle GO:0007049 IEA
    maintenance of protein location in nucleus GO:0051457 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    centrosome GO:0005813 ISO
    Golgi apparatus GO:0005794 ISO
    mitochondrion GO:0005739 IEA
    nucleus GO:0005634 ISO
    mitochondrial intermembrane space GO:0005758 ISO
    intracellular GO:0005622 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Arl2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Arl2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDE6D  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Arl2 is involved
PathwayEvidenceSource
Post-chaperonin tubulin folding pathway IEA Reactome
Regulation of insulin secretion IEA Reactome





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