Gene description for Hsd17b12
Gene name hydroxysteroid (17-beta) dehydrogenase 12
Gene symbol Hsd17b12
Other names/aliases 2610510O05Rik
AI172963
KIK-I
Kik1
Species Mus musculus
 Database cross references - Hsd17b12
ExoCarta ExoCarta_56348
Entrez Gene 56348
UniProt O70503  
 Hsd17b12 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Hsd17b12
Molecular Function
    collagen binding GO:0005518 IDA
    heparin binding GO:0008201 IDA
    oxidoreductase activity GO:0016491 IEA
    fibronectin binding GO:0001968 IDA
    estradiol 17-beta-dehydrogenase activity GO:0004303 IEA
Biological Process
    positive regulation of cell-substrate adhesion GO:0010811 IDA
    metabolic process GO:0008152 IEA
    steroid biosynthetic process GO:0006694 IEA
    lipid metabolic process GO:0006629 IEA
    extracellular matrix organization GO:0030198 IDA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    proteinaceous extracellular matrix GO:0005578 IDA
 Experiment description of studies that identified Hsd17b12 in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hsd17b12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hsd17b12 is involved
PathwayEvidenceSource
Synthesis of very long-chain fatty acyl-CoAs IEA Reactome





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