Gene description for Trip4
Gene name thyroid hormone receptor interactor 4
Gene symbol Trip4
Other names/aliases 4930558E03Rik
ASC-1
Asc1
BB191711
Species Mus musculus
 Database cross references - Trip4
ExoCarta ExoCarta_56404
Entrez Gene 56404
UniProt Q9QXN3  
 Trip4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trip4
Molecular Function
    zinc ion binding GO:0008270 IEA
    metal ion binding GO:0046872 IEA
    ligand-dependent nuclear receptor binding GO:0016922 ISO
    transcription coactivator activity GO:0003713 ISO
    histone acetyltransferase binding GO:0035035 ISO
    protease binding GO:0002020 ISO
    ubiquitin-like protein ligase binding GO:0044389 ISO
    estrogen receptor binding GO:0030331 ISO
Biological Process
    toxin transport GO:1901998 IMP
    transcription, DNA-templated GO:0006351 IEA
    intracellular estrogen receptor signaling pathway GO:0030520 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoskeleton GO:0005856 IEA
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Trip4 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trip4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trip4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here