Gene description for Clec7a
Gene name C-type lectin domain family 7, member a
Gene symbol Clec7a
Other names/aliases BGR
Clecsf12
beta-GR
Species Mus musculus
 Database cross references - Clec7a
ExoCarta ExoCarta_56644
Vesiclepedia VP_56644
Entrez Gene 56644
UniProt Q6QLQ4  
 Clec7a identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Clec7a
Molecular Function
    opsonin binding GO:0001846 IDA
    (1->3)-beta-D-glucan binding GO:0001872 IBA
    (1->3)-beta-D-glucan binding GO:0001872 IDA
    (1->3)-beta-D-glucan binding GO:0001872 ISO
    (1->3)-beta-D-glucan immune receptor activity GO:0001874 IDA
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 ISO
    polysaccharide binding GO:0030247 IDA
    pattern recognition receptor activity GO:0038187 IBA
    pattern recognition receptor activity GO:0038187 IDA
    pattern recognition receptor activity GO:0038187 IMP
    pattern recognition receptor activity GO:0038187 ISO
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    cell activation GO:0001775 IDA
    response to yeast GO:0001878 IDA
    response to yeast GO:0001878 IDA
    detection of yeast GO:0001879 IDA
    detection of yeast GO:0001879 IDA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 IDA
    response to molecule of fungal origin GO:0002238 IDA
    leukocyte activation involved in immune response GO:0002366 IDA
    positive regulation of cytokine production involved in immune response GO:0002720 IBA
    positive regulation of cytokine production involved in immune response GO:0002720 IDA
    positive regulation of dendritic cell cytokine production GO:0002732 IDA
    positive regulation of dendritic cell cytokine production GO:0002732 IMP
    cell surface pattern recognition receptor signaling pathway GO:0002752 IDA
    phagocytosis, recognition GO:0006910 IBA
    phagocytosis, recognition GO:0006910 IDA
    phagocytosis, recognition GO:0006910 ISO
    phagocytosis, engulfment GO:0006911 IDA
    inflammatory response GO:0006954 IEA
    cell recognition GO:0008037 ISO
    positive regulation of cell population proliferation GO:0008284 ISO
    positive regulation of gene expression GO:0010628 ISO
    detection of fungus GO:0016046 ISO
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of protein-containing complex assembly GO:0031334 ISO
    detection of molecule of fungal origin GO:0032491 IDA
    detection of molecule of fungal origin GO:0032491 ISO
    positive regulation of type II interferon production GO:0032729 ISO
    positive regulation of interleukin-1 beta production GO:0032731 ISO
    positive regulation of interleukin-10 production GO:0032733 IMP
    positive regulation of interleukin-10 production GO:0032733 ISO
    positive regulation of interleukin-12 production GO:0032735 ISO
    positive regulation of interleukin-2 production GO:0032743 IMP
    positive regulation of interleukin-2 production GO:0032743 ISO
    positive regulation of interleukin-23 production GO:0032747 IMP
    positive regulation of interleukin-6 production GO:0032755 IMP
    positive regulation of interleukin-6 production GO:0032755 ISO
    positive regulation of interleukin-8 production GO:0032757 ISO
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    positive regulation of stress-activated MAPK cascade GO:0032874 IDA
    positive regulation of superoxide anion generation GO:0032930 ISO
    regulation of canonical NF-kappaB signal transduction GO:0043122 IBA
    regulation of canonical NF-kappaB signal transduction GO:0043122 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IDA
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    positive regulation of phagocytosis GO:0050766 IDA
    positive regulation of phagocytosis GO:0050766 ISO
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    positive regulation of lymphocyte activation GO:0051251 ISO
    positive regulation of killing of cells of another organism GO:0051712 ISO
    positive regulation of respiratory burst GO:0060267 ISO
    antifungal innate immune response GO:0061760 IDA
    antifungal innate immune response GO:0061760 IMP
    regulation of calcineurin-NFAT signaling cascade GO:0070884 IMP
    cellular response to molecule of fungal origin GO:0071226 IDA
    cellular response to molecule of fungal origin GO:0071226 ISO
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 ISO
    positive regulation of wound healing GO:0090303 ISO
    cell-cell adhesion GO:0098609 IDA
    positive regulation of cytokine production involved in inflammatory response GO:1900017 ISO
    positive regulation of cell maturation GO:1903431 ISO
    positive regulation of T-helper 17 type immune response GO:2000318 IMP
    positive regulation of cysteine-type endopeptidase activity GO:2001056 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Clec7a in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Clec7a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Clec7a is involved
No pathways found





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