Gene description for Clec7a
Gene name C-type lectin domain family 7, member a
Gene symbol Clec7a
Other names/aliases BGR
Clecsf12
beta-GR
Species Mus musculus
 Database cross references - Clec7a
ExoCarta ExoCarta_56644
Entrez Gene 56644
UniProt Q6QLQ4  
 Clec7a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Clec7a
Molecular Function
    signaling pattern recognition receptor activity GO:0008329 ISO
    polysaccharide binding GO:0030247 IDA
    opsonin binding GO:0001846 IDA
    (1->3)-beta-D-glucan binding GO:0001872 IDA
    metal ion binding GO:0046872 IEA
    (1->3)-beta-D-glucan receptor activity GO:0001874 IDA
    carbohydrate binding GO:0030246 ISO
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    innate immune response GO:0045087 IDA
    cellular response to molecule of fungal origin GO:0071226 IDA
    pattern recognition receptor signaling pathway GO:0002221 ISO
    response to yeast GO:0001878 IDA
    response to molecule of fungal origin GO:0002238 IDA
    cell recognition GO:0008037 ISO
    single organismal cell-cell adhesion GO:0016337 IDA
    phagocytosis, recognition GO:0006910 ISO
    detection of yeast GO:0001879 IDA
    inflammatory response GO:0006954 IEA
    immune system process GO:0002376 IEA
    leukocyte activation involved in immune response GO:0002366 IDA
    positive regulation of phagocytosis GO:0050766 IDA
    cell surface pattern recognition receptor signaling pathway GO:0002752 IDA
    phagocytosis, engulfment GO:0006911 IDA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    external side of plasma membrane GO:0009897 IDA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Clec7a in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Clec7a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Clec7a is involved
PathwayEvidenceSource
CLEC7A (Dectin-1) signaling IEA Reactome





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