Gene description for Lgals1
Gene name lectin, galactoside-binding, soluble, 1
Gene symbol Lgals1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lgals1
ExoCarta ExoCarta_56646
Entrez Gene 56646
UniProt P11762  
 Lgals1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lgals1
Molecular Function
    protein homodimerization activity GO:0042803 IDA
    laminin binding GO:0043236 IDA
    glycoprotein binding GO:0001948 IPI
    carbohydrate binding GO:0030246 ISO
    lactose binding GO:0030395 IDA
    galactoside binding GO:0016936 IEA
    poly(A) RNA binding GO:0044822 ISO
    signal transducer activity GO:0004871 ISO
Biological Process
    T cell costimulation GO:0031295 ISO
    multicellular organismal response to stress GO:0033555 IEP
    signal transduction GO:0007165 ISO
    apoptotic process GO:0006915 IEA
    cellular response to glucose stimulus GO:0071333 IEP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
    response to axon injury GO:0048678 IEP
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    myoblast differentiation GO:0045445 ISO
    negative regulation of neuron projection development GO:0010977 IMP
    cellular response to organic cyclic compound GO:0071407 IEP
    positive regulation of erythrocyte aggregation GO:0034120 IDA
    response to drug GO:0042493 IEP
    plasma cell differentiation GO:0002317 ISO
Subcellular Localization
    cell surface GO:0009986 IDA
    nucleus GO:0005634 IDA
    extracellular exosome GO:0070062 ISO
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 IDA
    intracellular GO:0005622 ISO
    extracellular matrix GO:0031012 ISO
 Experiment description of studies that identified Lgals1 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lgals1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lgals1 is involved
No pathways found





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