Gene description for Lgals1
Gene name lectin, galactoside-binding, soluble, 1
Gene symbol Lgals1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lgals1
ExoCarta ExoCarta_56646
Vesiclepedia VP_56646
Entrez Gene 56646
UniProt P11762  
 Lgals1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lgals1
Molecular Function
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
    carbohydrate binding GO:0030246 ISO
    lactose binding GO:0030395 IBA
    lactose binding GO:0030395 IDA
    identical protein binding GO:0042802 IPI
    laminin binding GO:0043236 IBA
    laminin binding GO:0043236 IDA
    receptor ligand activity GO:0048018 IEA
    receptor ligand activity GO:0048018 ISO
Biological Process
    plasma cell differentiation GO:0002317 IEA
    plasma cell differentiation GO:0002317 ISO
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 IEA
    response to xenobiotic stimulus GO:0009410 IEP
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    negative regulation of neuron projection development GO:0010977 IMP
    T cell costimulation GO:0031295 IEA
    T cell costimulation GO:0031295 ISO
    positive regulation of erythrocyte aggregation GO:0034120 IDA
    response to isolation stress GO:0035900 IEP
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    maintenance of protein location GO:0045185 ISO
    myoblast differentiation GO:0045445 IEA
    myoblast differentiation GO:0045445 ISO
    positive regulation of viral entry into host cell GO:0046598 IEA
    positive regulation of viral entry into host cell GO:0046598 ISO
    response to axon injury GO:0048678 IEP
    positive regulation of inflammatory response GO:0050729 IEA
    positive regulation of inflammatory response GO:0050729 ISO
    cellular response to glucose stimulus GO:0071333 IEP
    cellular response to organic cyclic compound GO:0071407 IEP
    cell-cell adhesion GO:0098609 IEA
    cell-cell adhesion GO:0098609 ISO
    negative regulation of T-helper 17 cell lineage commitment GO:2000329 IEA
    negative regulation of T-helper 17 cell lineage commitment GO:2000329 ISO
    positive regulation of dendritic cell differentiation GO:2001200 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 IEA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 IDA
    galectin complex GO:1990724 IEA
    galectin complex GO:1990724 ISO
 Experiment description of studies that identified Lgals1 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lgals1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Gja1  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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