Gene description for Alg2
Gene name asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)
Gene symbol Alg2
Other names/aliases 1110018A23Rik
Species Mus musculus
 Database cross references - Alg2
ExoCarta ExoCarta_56737
Entrez Gene 56737
UniProt Q9DBE8  
 Alg2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Alg2
Molecular Function
    alpha-1,3-mannosyltransferase activity GO:0000033 ISO
    transferase activity GO:0016740 IEA
    protein heterodimerization activity GO:0046982 ISO
    transferase activity, transferring glycosyl groups GO:0016757 IEA
    calcium-dependent protein binding GO:0048306 ISO
    protein N-terminus binding GO:0047485 ISO
    GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity GO:0004378 IEA
    glycolipid 6-alpha-mannosyltransferase activity GO:0033164 IEA
Biological Process
    biosynthetic process GO:0009058 IEA
    mannosylation GO:0097502 ISO
    dolichol-linked oligosaccharide biosynthetic process GO:0006488 ISO
    protein glycosylation in endoplasmic reticulum GO:0033577 ISO
    response to calcium ion GO:0051592 ISO
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    cytoplasm GO:0005737 ISO
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 ISO
    nucleus GO:0005634 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Alg2 in exosomes
Experiment ID 188
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Alg2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CPNE2 221184
Two-hybrid Homo sapiens
2 CPNE1 8904
Reconstituted Complex Homo sapiens
3 CPNE4 131034
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
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