Gene description for Leprot
Gene name leptin receptor overlapping transcript
Gene symbol Leprot
Other names/aliases Ob-Rgrp
Obrgrp
Species Rattus norvegicus
 Database cross references - Leprot
ExoCarta ExoCarta_56766
Vesiclepedia VP_56766
Entrez Gene 56766
UniProt Q9JLS8  
 Leprot identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Leprot
Molecular Function
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
Biological Process
    late endosome to vacuole transport via multivesicular body sorting pathway GO:0032511 IBA
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IEA
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 ISO
    negative regulation of growth hormone receptor signaling pathway GO:0060400 IBA
    negative regulation of growth hormone receptor signaling pathway GO:0060400 IEA
    negative regulation of growth hormone receptor signaling pathway GO:0060400 ISO
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    negative regulation of protein localization to cell surface GO:2000009 IEA
    negative regulation of protein localization to cell surface GO:2000009 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endosome GO:0005768 IBA
    endosome GO:0005768 ISO
    Golgi apparatus GO:0005794 ISO
    endosome membrane GO:0010008 IEA
 Experiment description of studies that identified Leprot in sEVs
1
Experiment ID 90
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70|HSP90|TSG101|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Leprot
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Leprot is involved
No pathways found





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