Gene description for Acpp
Gene name acid phosphatase, prostate
Gene symbol Acpp
Other names/aliases 5'-NT
Acpp11
FRAP
Ppal
RNACPP11
pap
Species Rattus norvegicus
 Database cross references - Acpp
ExoCarta ExoCarta_56780
Entrez Gene 56780
UniProt P20646  
 Acpp identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Acpp
Molecular Function
    5'-nucleotidase activity GO:0008253 ISO
    thiamine phosphate phosphatase activity GO:0042131 ISO
    choline binding GO:0033265 IDA
    acid phosphatase activity GO:0003993 ISO
    lysophosphatidic acid phosphatase activity GO:0052642 ISO
    phosphatase activity GO:0016791 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IDA
Biological Process
    purine nucleobase metabolic process GO:0006144 ISO
    dephosphorylation GO:0016311 ISO
    regulation of sensory perception of pain GO:0051930 ISO
    positive regulation of adenosine receptor signaling pathway GO:0060168 ISO
    nucleotide metabolic process GO:0009117 ISO
    adenosine metabolic process GO:0046085 ISO
    thiamine metabolic process GO:0006772 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    extracellular exosome GO:0070062 ISO
    Golgi cisterna GO:0031985 IDA
    integral component of membrane GO:0016021 ISO
    apical part of cell GO:0045177 IDA
    secretory granule GO:0030141 IDA
    intracellular GO:0005622 ISO
    multivesicular body GO:0005771 IDA
    lysosomal membrane GO:0005765 ISO
    filopodium GO:0030175 ISO
    nucleus GO:0005634 ISO
    extracellular space GO:0005615 ISO
    vesicle membrane GO:0012506 ISO
 Experiment description of studies that identified Acpp in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Acpp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acpp is involved
No pathways found





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