Gene description for Cd86
Gene name CD86 molecule
Gene symbol Cd86
Other names/aliases B7-2
Species Rattus norvegicus
 Database cross references - Cd86
ExoCarta ExoCarta_56822
Vesiclepedia VP_56822
Entrez Gene 56822
 Cd86 identified in sEVs derived from the following tissue/cell type
Dendritic cells 19812188    
 Gene ontology annotations for Cd86
Molecular Function
    signaling receptor binding GO:0005102 IPI
    receptor ligand activity GO:0048018 ISO
Biological Process
    response to yeast GO:0001878 IEP
    toll-like receptor signaling pathway GO:0002224 ISO
    T cell proliferation involved in immune response GO:0002309 IEP
    positive regulation of immunoglobulin production GO:0002639 ISO
    negative regulation of T cell anergy GO:0002668 IMP
    immune response GO:0006955 IBA
    cell surface receptor signaling pathway GO:0007166 IBA
    response to xenobiotic stimulus GO:0009410 IEP
    T cell costimulation GO:0031295 IBA
    response to lipopolysaccharide GO:0032496 IEP
    toll-like receptor 3 signaling pathway GO:0034138 ISO
    response to type II interferon GO:0034341 IEP
    positive regulation of T cell proliferation GO:0042102 IBA
    positive regulation of T cell proliferation GO:0042102 IMP
    positive regulation of T cell proliferation GO:0042102 ISO
    positive regulation of activated T cell proliferation GO:0042104 IDA
    T cell activation GO:0042110 ISO
    B cell activation GO:0042113 ISO
    B cell activation GO:0042113 ISO
    negative regulation of T cell proliferation GO:0042130 IBA
    myeloid dendritic cell differentiation GO:0043011 IEP
    defense response to virus GO:0051607 IEP
    defense response to virus GO:0051607 ISO
    cellular response to lipopolysaccharide GO:0071222 IBA
    cellular response to lipopolysaccharide GO:0071222 IEP
    cellular response to lipopolysaccharide GO:0071222 ISO
    cellular response to metal ion GO:0071248 IEP
    cellular response to cytokine stimulus GO:0071345 IEP
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 IDA
    centriolar satellite GO:0034451 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cd86 in sEVs
1
Experiment ID 70
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19812188    
Organism Rattus norvegicus
Experiment description Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII.
Authors "Miksa M, Wu R, Dong W, Komura H, Amin D, Ji Y, Wang Z, Wang H, Ravikumar TS, Tracey KJ, Wang P"
Journal name JIMMU
Publication year 2009
Sample Dendritic cells
Sample name Bone marrow-derived mature dendritic cells
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Cd86
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd86 is involved
No pathways found





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