Gene description for Haao
Gene name 3-hydroxyanthranilate 3,4-dioxygenase
Gene symbol Haao
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Haao
ExoCarta ExoCarta_56823
Entrez Gene 56823
UniProt P46953  
 Haao identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Haao
Molecular Function
    oxygen binding GO:0019825 IDA
    ferrous iron binding GO:0008198 ISO
    3-hydroxyanthranilate 3,4-dioxygenase activity GO:0000334 ISO
    iron ion binding GO:0005506 IDA
Biological Process
    neuron cellular homeostasis GO:0070050 ISO
    quinolinate metabolic process GO:0046874 IDA
    quinolinate biosynthetic process GO:0019805 IEA
    oxidation-reduction process GO:0055114 ISO
    response to cadmium ion GO:0046686 ISO
    'de novo' NAD biosynthetic process from tryptophan GO:0034354 IEA
    response to zinc ion GO:0010043 ISO
    anthranilate metabolic process GO:0043420 IEA
    tryptophan catabolic process GO:0006569 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    mitochondrial membrane GO:0031966 IDA
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Haao in exosomes
1
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Haao
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Haao is involved
PathwayEvidenceSource
Tryptophan catabolism IEA Reactome





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