Gene description for ATP10A
Gene name ATPase, class V, type 10A
Gene symbol ATP10A
Other names/aliases ATP10C
ATPVA
ATPVC
Species Homo sapiens
 Database cross references - ATP10A
ExoCarta ExoCarta_57194
Vesiclepedia VP_57194
Entrez Gene 57194
HGNC 13542
MIM 605855
UniProt O60312  
 ATP10A identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ATP10A
Molecular Function
    magnesium ion binding GO:0000287 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    phosphatidylcholine floppase activity GO:0090554 IEA
    ATPase-coupled intramembrane lipid transporter activity GO:0140326 IBA
    ATPase-coupled intramembrane lipid transporter activity GO:0140326 NAS
    ATPase-coupled intramembrane lipid transporter activity GO:0140326 TAS
    phosphatidylcholine flippase activity GO:0140345 IDA
    glycosylceramide flippase activity GO:0140351 IDA
Biological Process
    regulation of cell shape GO:0008360 NAS
    monoatomic ion transmembrane transport GO:0034220 TAS
    phospholipid translocation GO:0045332 IBA
    phospholipid translocation GO:0045332 NAS
    positive regulation of membrane tubulation GO:1903527 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 NAS
    phospholipid-translocating ATPase complex GO:1990531 IDA
    phospholipid-translocating ATPase complex GO:1990531 IPI
 Experiment description of studies that identified ATP10A in sEVs
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP10A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NLRP1  
Affinity Capture-MS Homo sapiens
2 HSPA8 3312
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATP10A is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Ion transport by P-type ATPases TAS Reactome
Transport of small molecules TAS Reactome





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