Gene description for Tbx20
Gene name T-box 20
Gene symbol Tbx20
Other names/aliases 9430010M06Rik
AL022859
Tbx12
Species Mus musculus
 Database cross references - Tbx20
ExoCarta ExoCarta_57246
Entrez Gene 57246
UniProt Q9ES03  
 Tbx20 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tbx20
Molecular Function
    DNA binding GO:0003677 IDA
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 ISO
    RNA polymerase II transcription factor binding GO:0001085 IPI
    RNA polymerase II activating transcription factor binding GO:0001102 IPI
    RNA polymerase II transcription coactivator activity GO:0001105 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of transcription, DNA-templated GO:0006355 TAS
    transcription, DNA-templated GO:0006351 IEA
    blood circulation GO:0008015 IMP
    atrial septum morphogenesis GO:0060413 ISO
    transcription from RNA polymerase II promoter GO:0006366 ISO
    negative regulation of SMAD protein complex assembly GO:0010991 IDA
    pericardium morphogenesis GO:0003344 IMP
    endocardial cushion morphogenesis GO:0003203 IMP
    tricuspid valve development GO:0003175 IMP
    pulmonary valve formation GO:0003193 IMP
    embryonic heart tube morphogenesis GO:0003143 IMP
    heart looping GO:0001947 IMP
    dorsal/ventral pattern formation GO:0009953 IMP
    patterning of blood vessels GO:0001569 IMP
    cardiac chamber formation GO:0003207 IMP
    neuron migration GO:0001764 IMP
    embryonic heart tube development GO:0035050 IMP
    positive regulation of cardiac muscle cell proliferation GO:0060045 IMP
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    aortic valve development GO:0003176 IMP
    multicellular organismal development GO:0007275 IEA
    aortic valve morphogenesis GO:0003180 ISO
    cardiac right ventricle morphogenesis GO:0003215 IMP
    endocardial cushion formation GO:0003272 IMP
    embryonic heart tube elongation GO:0036306 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    regulation of epithelial to mesenchymal transition GO:0010717 NAS
    outflow tract septum morphogenesis GO:0003148 ISO
    muscle contraction GO:0006936 IMP
    foramen ovale closure GO:0035922 ISO
    visceral motor neuron differentiation GO:0021524 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    cell proliferation GO:0008283 IMP
    pulmonary vein morphogenesis GO:0060577 ISO
    outflow tract morphogenesis GO:0003151 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    cardiac muscle tissue morphogenesis GO:0055008 IMP
    cardiac septum development GO:0003279 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Tbx20 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tbx20
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tbx20 is involved
No pathways found





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