Gene description for Tbx20
Gene name T-box 20
Gene symbol Tbx20
Other names/aliases 9430010M06Rik
AL022859
Tbx12
Species Mus musculus
 Database cross references - Tbx20
ExoCarta ExoCarta_57246
Vesiclepedia VP_57246
Entrez Gene 57246
UniProt Q9ES03  
 Tbx20 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tbx20
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISO
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    DNA-binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IGI
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    branching involved in blood vessel morphogenesis GO:0001569 IMP
    cell fate specification GO:0001708 IBA
    heart looping GO:0001947 IBA
    heart looping GO:0001947 IMP
    heart looping GO:0001947 IMP
    embryonic heart tube morphogenesis GO:0003143 IMP
    outflow tract septum morphogenesis GO:0003148 IMP
    outflow tract septum morphogenesis GO:0003148 ISO
    outflow tract morphogenesis GO:0003151 IMP
    atrioventricular valve development GO:0003171 IMP
    tricuspid valve development GO:0003175 IMP
    aortic valve development GO:0003176 IMP
    aortic valve morphogenesis GO:0003180 IEA
    aortic valve morphogenesis GO:0003180 ISO
    pulmonary valve formation GO:0003193 IMP
    endocardial cushion morphogenesis GO:0003203 IMP
    cardiac chamber formation GO:0003207 IMP
    cardiac chamber formation GO:0003207 IMP
    cardiac right ventricle morphogenesis GO:0003215 IMP
    endocardial cushion formation GO:0003272 IMP
    cardiac septum development GO:0003279 IMP
    pericardium morphogenesis GO:0003344 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    muscle contraction GO:0006936 IMP
    blood circulation GO:0008015 IMP
    cell population proliferation GO:0008283 IMP
    dorsal/ventral pattern formation GO:0009953 IMP
    regulation of epithelial to mesenchymal transition GO:0010717 NAS
    positive regulation of epithelial to mesenchymal transition GO:0010718 IMP
    mesenchymal cell development GO:0014031 IMP
    visceral motor neuron differentiation GO:0021524 IMP
    positive regulation of BMP signaling pathway GO:0030513 IMP
    embryonic heart tube development GO:0035050 IGI
    embryonic heart tube development GO:0035050 IMP
    foramen ovale closure GO:0035922 IEA
    foramen ovale closure GO:0035922 ISO
    atrioventricular canal development GO:0036302 IMP
    embryonic heart tube elongation GO:0036306 IMP
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of apoptotic process GO:0043065 ISO
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    cardiac muscle tissue morphogenesis GO:0055008 IMP
    positive regulation of cardiac muscle cell proliferation GO:0060045 IMP
    negative regulation of SMAD protein signal transduction GO:0060392 IDA
    atrial septum morphogenesis GO:0060413 IEA
    atrial septum morphogenesis GO:0060413 ISO
    pulmonary vein morphogenesis GO:0060577 IEA
    pulmonary vein morphogenesis GO:0060577 ISO
    positive regulation of cell cycle process GO:0090068 IEA
    positive regulation of cell cycle process GO:0090068 ISO
    motor neuron migration GO:0097475 IMP
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Tbx20 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tbx20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Smarca4  
Phenotypic Suppression Mus musculus
View the network image/svg+xml
 Pathways in which Tbx20 is involved
No pathways found





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