Gene description for Xpo4
Gene name exportin 4
Gene symbol Xpo4
Other names/aliases B430309A01Rik
mKIAA1721
Species Mus musculus
 Database cross references - Xpo4
ExoCarta ExoCarta_57258
Vesiclepedia VP_57258
Entrez Gene 57258
UniProt Q9ESJ0  
 Xpo4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Xpo4
Molecular Function
    nuclear export signal receptor activity GO:0005049 IBA
    nuclear export signal receptor activity GO:0005049 ISO
    nuclear export signal receptor activity GO:0005049 ISS
    small GTPase binding GO:0031267 ISO
Biological Process
    protein export from nucleus GO:0006611 IBA
    protein export from nucleus GO:0006611 ISO
    protein transport GO:0015031 IEA
    positive regulation of protein export from nucleus GO:0046827 ISO
    nuclear export GO:0051168 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nuclear pore GO:0005643 IBA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Xpo4 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Xpo4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SRY  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 Sox2  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
3 Nanog  
Affinity Capture-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Xpo4 is involved
No pathways found





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