Gene description for Ccr1
Gene name chemokine (C-C motif) receptor 1
Gene symbol Ccr1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ccr1
ExoCarta ExoCarta_57301
Entrez Gene 57301
 Ccr1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ccr1
Molecular Function
    chemokine (C-C motif) ligand 7 binding GO:0035717 ISO
    C-C chemokine binding GO:0019957 ISO
    chemokine receptor activity GO:0004950 ISO
    phosphatidylinositol phospholipase C activity GO:0004435 ISO
    C-C chemokine receptor activity GO:0016493 ISO
    chemokine (C-C motif) ligand 5 binding GO:0071791 ISO
Biological Process
    metabolic process GO:0008152 ISO
    exocytosis GO:0006887 ISO
    negative regulation of innate immune response GO:0045824 ISO
    chemokine-mediated signaling pathway GO:0070098 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    cellular calcium ion homeostasis GO:0006874 ISO
    negative regulation of gene expression GO:0010629 ISO
    myeloid cell differentiation GO:0030099 ISO
    cell-cell signaling GO:0007267 ISO
    G-protein coupled receptor signaling pathway GO:0007186 ISO
    positive regulation of monocyte chemotaxis GO:0090026 ISO
    immune response GO:0006955 ISO
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of calcium ion transport GO:0051928 ISO
    negative regulation of bone mineralization GO:0030502 ISO
    cerebellum development GO:0021549 IEP
    inflammatory response GO:0006954 ISO
    positive regulation of osteoclast differentiation GO:0045672 ISO
    leukocyte chemotaxis GO:0030595 ISO
    calcium ion transport GO:0006816 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    cytosol GO:0005829 ISO
    external side of plasma membrane GO:0009897 ISO
    integral component of membrane GO:0016021 IEA
    neuronal cell body GO:0043025 IDA
 Experiment description of studies that identified Ccr1 in exosomes
1
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ccr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ccr1 is involved
No pathways found





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